Physician-authored deep dives into the science of longevity — peer-reviewed, plainly written, and relentlessly evidence-based.
EST. 2024 · SINGAPORE · UPDATED WEEKLY
The Journal · All Articles
Randomized trials suggest intermittent fasting can modestly improve weight, insulin sensitivity, and blood pressure—but results are mixed, and benefits often depend on calorie reduction and timing rather than magic. Here’s what the best evidence really shows, and how to apply it safely.
The midlife hormone transition is disruptive—but understandable and treatable when you know the levers to pull.
HOMA-IR estimates insulin resistance from fasting insulin and glucose, signaling risk years before diabetes. Here's what the evidence shows.
A single fitness metric outperforms cholesterol, blood pressure, and BMI as a predictor of mortality. Here is what the evidence says — and what to do about it.
How chronic sleep debt rewires the HPA axis — and what the latest UK Biobank data tell us.
Forty years after Harman, where the data really stand on free radicals, mtDNA, and the brain.
A 2.4M-adult meta-analysis settled the debate. Here is the clinical case for ApoB-first screening.
When the calories are matched, does the eating window still matter? The evidence is more nuanced than the headlines.
Forty years after Harman, where the data really stand on free radicals, mtDNA, and the brain.
One blood draw, once in your life — and a 30% adjustment to lifetime cardiovascular risk.
Resistance training is the most under-prescribed longevity intervention in medicine.
How methylation patterns became the most-cited proxy for biological age.
"The goal of longevity medicine is not to cheat death — it is to earn more of the life you want to live."
— Dr. Ari Sahebkashaf, MD
Our Commitment · Evidence First
Every article on this journal is grounded in peer-reviewed evidence. We cite our sources. We challenge the hype. We follow the science wherever it leads.
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